Remdesivir for severe acute respiratory syndrome coronavirus 2 causing COVID-19: An evaluation of the evidence
Identifieur interne : 000315 ( 2020/Analysis ); précédent : 000314; suivant : 000316Remdesivir for severe acute respiratory syndrome coronavirus 2 causing COVID-19: An evaluation of the evidence
Auteurs : Yu-Chen Cao [République populaire de Chine] ; Qi-Xin Deng [République populaire de Chine] ; Shi-Xue Dai [République populaire de Chine]Source :
- Travel Medicine and Infectious Disease [ 1477-8939 ] ; 2020.
Abstract
The novel coronavirus infection that initially found at the end of 2019 has attracted great attention. So far, the number of infectious cases has increased globally to more than 100 thousand and the outbreak has been defined as a pandemic situation, but there are still no “specific drug” available. Relevant reports have pointed out the novel coronavirus has 80% homology with SARS. In the difficulty where new synthesized drug cannot be applied immediately to patients, “conventional drug in new use” becomes a feasible solution. The first medication experience of the recovered patients in the US has led remdesivir to be the “specific drug”. China has also taken immediate action to put remdesivir into clinical trials with the purpose of applying it into clinical therapeutics for Corona Virus Disease 2019 (COVID-19). We started from the structure, immunogenicity, and pathogenesis of coronavirus infections of the novel coronavirus. Further, we analyzed the pharmacological actions and previous trials of remdesivir to identify the feasibility of conducting experiments on COVID-19.
Url:
DOI: 10.1016/j.tmaid.2020.101647
PubMed: 32247927
PubMed Central: 7151266
Affiliations:
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PMC:7151266Le document en format XML
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Cao</name><affiliation wicri:level="1"><nlm:aff id="aff1">The Second Clinical School, Southern Medical University, Guangzhou, 510515, Guangdong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Second Clinical School, Southern Medical University, Guangzhou, 510515, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Deng, Qi Xin" sort="Deng, Qi Xin" uniqKey="Deng Q" first="Qi-Xin" last="Deng">Qi-Xin Deng</name><affiliation wicri:level="1"><nlm:aff id="aff1">The Second Clinical School, Southern Medical University, Guangzhou, 510515, Guangdong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Second Clinical School, Southern Medical University, Guangzhou, 510515, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Dai, Shi Xue" sort="Dai, Shi Xue" uniqKey="Dai S" first="Shi-Xue" last="Dai">Shi-Xue Dai</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Gastroenterology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, South China University of Technology, Guangzhou, 510080, Guangdong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, South China University of Technology, Guangzhou, 510080, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author></analytic><series><title level="j">Travel Medicine and Infectious Disease</title><idno type="ISSN">1477-8939</idno><idno type="eISSN">1873-0442</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The novel coronavirus infection that initially found at the end of 2019 has attracted great attention. So far, the number of infectious cases has increased globally to more than 100 thousand and the outbreak has been defined as a pandemic situation, but there are still no “specific drug” available. Relevant reports have pointed out the novel coronavirus has 80% homology with SARS. In the difficulty where new synthesized drug cannot be applied immediately to patients, “conventional drug in new use” becomes a feasible solution. The first medication experience of the recovered patients in the US has led remdesivir to be the “specific drug”. China has also taken immediate action to put remdesivir into clinical trials with the purpose of applying it into clinical therapeutics for Corona Virus Disease 2019 (COVID-19). We started from the structure, immunogenicity, and pathogenesis of coronavirus infections of the novel coronavirus. Further, we analyzed the pharmacological actions and previous trials of remdesivir to identify the feasibility of conducting experiments on COVID-19.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Liu, W" uniqKey="Liu W">W. Liu</name></author><author><name sortKey="Morse, J S" uniqKey="Morse J">J.S. Morse</name></author><author><name sortKey="Lalonde, T" uniqKey="Lalonde T">T. Lalonde</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="W, M" uniqKey="W M">M. W</name></author><author><name sortKey="C, R" uniqKey="C R">R. C</name></author><author><name sortKey="Z, L" uniqKey="Z L">L. Z</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="L, H" uniqKey="L H">H. 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